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Search Results for " uric acid "

30

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20545	Benzarone Benzarona,Vasoc,苯扎隆,Venagil,Benzaronum	OAT	Membrane transporter/Ion channel
	Benzarone (Benzarona) 是人尿酸转运蛋白 1的有效抑制剂，IC50为 2.8 μM。它具有降低血清尿酸水平的作用。
T2397	Topiroxostat 托匹司他,FYX-051	P450; ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Topiroxostat (FYX-051) 是一种有效的口服黄嘌呤氧化还原酶 (XOR) 抑制剂，IC50=5.3 nM，Ki=5.7 nM。它还表现出弱的CYP3A4抑制活性 (18.6%)。它有用于高尿酸血症的研究潜力。
T15251	Etebenecid 乙磺舒,Urelim	Others	Others
	Etebenecid (Urelim) 是促尿酸排泄药，能够抑制青霉素自肾小管分泌。
T21302	UNC569 UNC 569	TAM Receptor	Tyrosine Kinase/Adaptors
	UNC569 (UNC 569) 是一种ATP 竞争性的、可逆、具有口服活性的Mer 激酶抑制剂，其IC50=2.9 nM，Ki=4.3 nM。它还抑制Axl 和Tyro3，IC50分别为 37 nM 和 48 nM。它可用于研究急性淋巴细胞白血病和非典型畸胎瘤/横纹肌瘤。
T79854	Lingdolinurad	OAT	Membrane transporter/Ion channel
	Lingdolinurad 是一种靶向 hURAT1的尿酸转运蛋白抑制剂，可用于研究高尿酸血症或痛风。
T5987	Potassium oxonate Oxonic Acid (potassium salt),氧嗪酸钾,Potassium otastat,Potassium azaorotate	Others	Others
	Potassium oxonate (Potassium azaorotate) 是用作尿酸酶抑制剂，都5-FU 磷酸化为5-fluorouridine-5'-monophosphate 具有抑制作用。
T21469	Cyclopenthiazide Cyclomethiazide,Su-8341,SU 8341,环戊噻嗪	Others	Others
	Cyclopenthiazide (Cyclomethiazide) 是一种噻嗪类利尿剂，用于治疗高血压和心力衰竭。减少钙离子和尿酸的排泄，增加钠和钾离子的排泄。
T60625	Tigulixostat
	Tigulixostat 是吲哚基杂芳羧酸的新型衍生物。Tigulixostat 是一种非嘌呤选择性的黄嘌呤氧化酶抑制剂，可降低尿酸的生成。
T15160	Dotinurad (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone	OAT	Membrane transporter/Ion channel
	Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) 是有效的尿酸盐重吸收选择性抑制剂，抑制尿酸盐转运蛋白 1的IC50为 37.2 nM，具有促尿酸排泄的作用。
T26619	Amitivir LY217896,LY 217896,阿米替韦,LY-217896	Others; Influenza Virus	Microbiology/Virology; Others
	Amitivir (LY 217896) 是一种噻二唑衍生物，对 A 和 B 型流感病毒均有效，对正粘病毒和副粘病毒具有广泛的抗病毒活性。
T61048	Puliginurad YL-90148	OAT	Membrane transporter/Ion channel
	Puliginurad (YL-90148) 是一种具有有效性和选择性的尿酸盐转运蛋白 (URAT) 抑制剂，对尿酸的重吸收有抑制作用。Puliginurad 可用于预防和治疗高尿酸血症和痛风。
T6875	Lesinurad RDEA594,雷西那德,来司诺雷	OAT	Membrane transporter/Ion channel
	Lesinurad (RDEA594) 是URAT1和OAT 抑制剂。Lesinurad 用作肾转运蛋白OAT1 和OAT3 的底物，Km 分别为 0.85 和 2 μM。
T77517	URAT1 inhibitor 7	OAT	Membrane transporter/Ion channel
	URAT1 inhibitor 7 是一种新型高效的人尿酸转运蛋白 URAT1 抑制剂 (IC50:12 nM)。URAT1 inhibitor 7 对 CYP2C9 具有抑制作用，IC50为4.2 μM。URAT1 inhibitor 7 可用于研究高尿酸血症和痛风。
T0782	Benzthiazide Aquatag,苄噻嗪,Lemazide,Dihydrex	Carbonic Anhydrase	Metabolism
	Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的 Ki 分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。
T20548	Parabanic acid NSC9789,NSC-9789,NSC 9789
	Parabanic acid is the oxidation product of uric acid by singlet oxygen.
T27697	JTT-552
	JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia.
T26490	AA 193 AA-193,AA193
	AA 193 selectively inhibits the presecretory reabsorption of uric acid.
T26710	Azapropazone DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85
	Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering
T68437	Febuxostat 67M-1
	Febuxostat 67M-1 is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation.
T13259	URAT1 inhibitor 1	OAT	Membrane transporter/Ion channel
	URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.
T71808	Tisopurine
	Tisopurine is a drug used in the treatment of gout in some countries. It reduces uric acid production through inhibiting an early stage in its production.
T69282	Febuxostat 67M-2
	Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation.
T69281	Febuxostat 67M-4
	Febuxostat 67M-4 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation.
T73617	Urate oxidase
	Urate oxidase (Uox) 尿酸氧化酶，即尿酸酶，常用于生化研究。Urate oxidase 是一种过氧化物酶，在大多数哺乳动物中催化尿酸氧化为尿囊素。
T76104	Xanthine oxidase 黄嘌呤氧化酶
	Xanthine oxidase 是一种黄嘌呤氧化还原酶，可产生活性氧 (ROS)，催化次黄嘌呤氧化为黄嘌呤，进一步催化黄嘌呤氧化为尿酸。
T79177	URAT1&XO inhibitor 2	Xanthine Oxidase	Metabolism
	URAT1&XO inhibitor 2 (Compound BDEO)是一种针对xanthine oxidase (黄嘌呤氧化酶) 及URAT1的双重抑制剂，对xanthine oxidase展现出优异的抑制效果，IC50值为3.3 μM。该化合物在表达URAT1的HEK293细胞中显著抑制尿酸的摄取，其Ki值达到0.145 μM。在动物模型中，URAT1&XO inhibitor 2有效降低高尿酸血症小鼠的血清尿酸水平，并增加尿酸的排泄。该化合物主要用于高尿酸血症的研究。
T71326	1,3,7-Trimethyluric Acid-d9
	1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.
T60626	Xanthine oxidase-IN-7
	Xanthine oxidase-IN-7 (compound1h) 是一种口服的黄嘌呤氧化酶(XO)抑制剂 (IC50 = 0.36 μM)。Xanthine oxidase-IN-7 可有效降低血清尿酸水平，在高尿酸血症和痛风的研究中具有潜力。
T60935	H-Tyr-Phe-OH
	H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) 可用作区分良性甲状腺结节和甲状腺癌的生物标志物。H-Tyr-Phe-OH 是一种口服活性的血管紧张素转换酶抑制剂，在50 μM 时抑制率为 48%。H-Tyr-Phe-OH 具有黄嘌呤氧化酶抑制活性 (降低尿酸) ，可调节中性粒细胞样细胞中 IL-8 的产生。
T36660	Olsalazine-13C6 Olsalazine-13C6
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ...

化合物

Cat.No: T20545

Synonym: Benzarona,Vasoc,苯扎隆,Venagil,Benzaronum

Target: OAT

Cat.No: T2397

Synonym: 托匹司他,FYX-051

Target: P450, ROS, Xanthine Oxidase

Cat.No: T15251

Synonym: 乙磺舒,Urelim

Target: Others

Cat.No: T21302

Synonym: UNC 569

Target: TAM Receptor

Cat.No: T79854

Target: OAT

Potassium oxonate

Cat.No: T5987

Synonym: Oxonic Acid (potassium salt),氧嗪酸钾,Potassium otastat,Potassium azaorotate

Target: Others

Cyclopenthiazide

Cat.No: T21469

Synonym: Cyclomethiazide,Su-8341,SU 8341,环戊噻嗪

Target: Others

Cat.No: T60625

Cat.No: T15160

Synonym: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone

Target: OAT

Cat.No: T26619

Synonym: LY217896,LY 217896,阿米替韦,LY-217896

Target: Others, Influenza Virus

Cat.No: T61048

Synonym: YL-90148

Target: OAT

Cat.No: T6875

Synonym: RDEA594,雷西那德,来司诺雷

Target: OAT

URAT1 inhibitor 7

Cat.No: T77517

Target: OAT

Cat.No: T0782

Synonym: Aquatag,苄噻嗪,Lemazide,Dihydrex

Target: Carbonic Anhydrase

Parabanic acid

Cat.No: T20548

Synonym: NSC9789,NSC-9789,NSC 9789

Cat.No: T27697

Cat.No: T26490

Synonym: AA-193,AA193

Cat.No: T26710

Synonym: DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85

Febuxostat 67M-1

Cat.No: T68437

URAT1 inhibitor 1

Cat.No: T13259

Target: OAT

Cat.No: T71808

Febuxostat 67M-2

Cat.No: T69282

Febuxostat 67M-4

Cat.No: T69281

Cat.No: T73617

Xanthine oxidase

Cat.No: T76104

Synonym: 黄嘌呤氧化酶

URAT1&XO inhibitor 2

Cat.No: T79177

Target: Xanthine Oxidase

1,3,7-Trimethyluric Acid-d9

Cat.No: T71326

Xanthine oxidase-IN-7

Cat.No: T60626

Cat.No: T60935

Olsalazine-13C6

Cat.No: T36660

Synonym: Olsalazine-13C6

Cat. No.	Product Name	Target	Signaling Pathways
T0626	Uric Acid 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase	Immunology/Inflammation; Metabolism; NF-κB
	Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
T41242	Uric acid sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂，是一种有效的、常见的抗氧化剂，有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，对脂质过氧化有抑制作用，与痛风性关节病的发病机理和草酸钙结石的形成有关。
T4746	Purine 7H-Imidazo(4,5-d)pyrimidine,嘌呤	Others; Endogenous Metabolite	Metabolism; Others
	Purine (7H-Imidazo(4,5-d)pyrimidine) 是内源性代谢产物的一种。
T1362	Hypoxanthine 次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin	Others; Endogenous Metabolite	Metabolism; Others
	Hypoxanthine (Purin-6-ol)，也被称为 purine-6-ol 或 Hyp，是一种天然存在的嘌呤衍生物，是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下，Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤，黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。
T0665	Xanthine 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine	Endogenous Metabolite; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Xanthine (Isoxanthine) 是一种植物生物碱，存在于茶、咖啡和可可中。Xanthine 是温和的中枢神经系统激活剂，也是嘌呤降解途径的中间产物。
T0256	Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate	Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。
T35954	Allantoic acid
	Allantoic acid, a byproduct of uric acid degradation, is implicated in purine metabolism [1][2][3].
T7814L	Alloxan NSC 7169,NSC7169,NSC-7169
	Alloxan is an acidic compound formed by the oxidation of URIC ACID.

天然产物

Cat.No: T0626

Synonym: 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

Uric acid sodium

Cat.No: T41242

Target: Reactive Oxygen Species

Cat.No: T4746

Synonym: 7H-Imidazo(4,5-d)pyrimidine,嘌呤

Target: Others, Endogenous Metabolite

Cat.No: T1362

Synonym: 次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin

Target: Others, Endogenous Metabolite

Cat.No: T0665

Synonym: 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine

Target: Endogenous Metabolite, Adenosine Receptor

Citric acid trilithium salt tetrahydrate

Cat.No: T0256

Synonym: Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate

Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR

Allantoic acid

Cat.No: T35954

Cat.No: T7814L

Synonym: NSC 7169,NSC7169,NSC-7169

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